Objectives : For investigation of the clinical significance of the number of positive cores of chronic inflammation in prostate needle biopsy specimen, we look into several clinical characteristics and the number of positive cores of chronic inflammation in twelve core prostate biopsy specimen.
Materials and methods : Between March 2016 to Feburary 2018, total 256 patients underwent transrectal ultrasound guided twelve core prostate needle biopsy. Except the patients with prostate carcinoma, we reviewed medical records of 142 patients including prostate specific antigen (PSA), prostate volume, total IPSS score, QoL score, IPSS question 1 to 7, IPSS voiding subscore, IPSS storage subscore and the numbers of cores with chronic inflammation. For evaluation of the clinical effect of the chronic inflammation in prostate biopsy, simple and multiple regression analyses were done. We excluded the patients who underwent prostate surgery, diagnosed symptomatic chronic prostatitis, and had alpha blockers, antiinflammatory drugs, antibiotics, diuretics, antimuscarinic agents, and 5 alpha reductase inhibitors within 4 weeks.
Results : The patients with complete medical records and not relevent with exclusion criteria were 97 patients. The mean age, PSA , prostate volume was 66.5±9.5, 8.38±14.2, 53.3±19.8, respectively. The mean total IPSS score, QoL score, IPSS voiding subscore, IPSS storage subscore was 11.9, 3.3, 6.6, 5.2 respectively. The mean each IPSS question 1 to 7 was 1.9, 1.9, 1.4, 1.6, 2.1, 1.2, 1.9, respectively and the mean numbers of cores with chronic inflammation was 5.0. By simple regression analysis, the numbers of cores with chronic inflammation had a positively related trend with PSA (p=0.072), IPSS question 2 – frequency (p=0.072), and IPSS question 3 - intermittency (p=0.069). After multiple regression analysis (R2=0.146), PSA (p=0.028, B=0.71) and IPSS question 2 – frequency (p=0.046, B=1.575) were statistically significant.
Conclusion : PSA and urinary frequency were increased with the number of cores with chronic inflammation in the prostate biopsy. However, total IPSS score, voiding and storage IPSS subscore were not related.
