Recent epidemiologic and clinical data suggest that metabolic syndrome is involved in the pathogenesis and progression of prostatic disease such as benign prostatic hyperplasia and prostate cancer. The purpose of our study was to assess to relation between subcutaneous adipose tissue, visceral adipose tissue, and prostate cancer grade and stage in Korean patients.
Materials and methods: Between 2010 and October 2012, 168 patients underwent radical prostatectomy at a tertiary center. Radical prostatectomy was performed by three surgeons. 127 patients were enrolled and the data were collected retrospectively in medical records. Each subject underwent cross-sectional CT scan of the abdomen at the level of L4. Assessment of total, visceral and subcutaneous abdominal fat compartments was performed by single slice CT. Analyses were performed using Alice software (version 4.3.9; Parexel, Waltham, MA).
Results: The median age was 66 years. 61 (48%) patients had low–grade (Gleason score ≤6) and 66 (52%) patients had high-grade cancer (Gleason score ≥ 7). 91 (72%) patients had pT2 stage cancer and 36 (28%) patients had pT3 stage cancer. There were performed to assess the association of the visceral adipose tissue, subcutaneous adipose tissue, Total adipose tissue, area ratio (V/V+S, %), outer circumference (cm). In low-grade group and high grade, the visceral adipose tissue (98.5±56.4, 112.3±65.9), subcutaneous adipose tissue (110.2±55.5, 116.3±58.4), total adipose tissue (208.7±106.6, 228.7±111.3), area ratio (47.1±8.3, 48.8±10.5) and outer circumference (80.8±8.3, 84.3±7.8) were not significantly different. In pT2 stage group and pT3 stage group, the visceral adipose tissue (104.8±64.0, 110.1±53.2), subcutaneous adipose tissue (109.1±52.3, 130.2±70.9), total adipose tissue (213.8±107.3, 240.2±115.7), area ratio (48.2±9.8, 47.1±8.8) and outer circumference (81.9±8.2, 85.3±7.8) were not significantly different.
Conclusion: In Western, Obesity defined by BMI and Waist circumference seems to be associated with prostate cancer and, more specifically, with high-grade disease. But our study showed abdominal obesity is not associated about prostate cancer stage and grade in Korean.